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In this eye-opening episode, Dr. Joshua Sharp dives deep into the secret powerhouse nutrient Vitamin B1 (thiamine), a vitamin many are unknowingly deficient in. Discover how thiamine influences your energy, mood, brain function, and autonomic nervous system health, and why deficiency is linked to conditions like chronic fatigue, POTS, depression, anxiety, and more.

Learn about the best food sources, high-absorption supplement forms like benfotiamine and TTFD, and an important metabolic test (MVX Plus) that can reveal hidden deficiencies. Armed with clinical evidence and practical advice, this episode empowers you to recognize, prevent, and treat this often-overlooked nutrient gap for lasting health improvements.

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00:00 Unlocking the Secret Nutrient: Thiamin
01:29 The Vital Role of Thiamin in Energy Production
03:42 Understanding Thiamin Deficiency and Its Symptoms
05:31 The Seriousness of Beriberi and Its Implications
06:46 Thiamin's Impact on Mental Health
11:24 Dietary Sources and Supplementation of Thiamin
16:11 Testing for Thiamin Deficiency

Key Resources and References:

Gibson GE et al. "Benfotiamine and Cognitive Decline in Alzheimer’s Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial." J Alzheimers Dis. 2020;78(3):989–1010. PMC7880246
Lonsdale D, Marrs C. Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition. Elsevier, 2017.
Rindi G et al. "Hiding in Plain Sight: Modern Thiamine Deficiency." Nutrients. 2021;13(10):3516. PMC
NIH StatPearls. "Vitamin B1 (Thiamine) Deficiency." National Center for Biotechnology Information. 2024. Link
Research on benfotiamine’s superior bioavailability and therapeutic benefits: PMID 32888286
Nutritional impact on thiamine status: Bender DA. Nutritional Biochemistry of the Vitamins. Cambridge University Press, 2003.
MVX Plus metabolomic testing: LabCorp MVX Plus Test