Methionine Restriction Extends Lifespan: Roles For SCFAs And FGF21, But Not Calorie Restriction

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Papers referenced in the video:
Dietary Methionine via Dose-Dependent Inhibition of Short-Chain Fatty Acid Production Capacity Contributed to a Potential Risk of Cognitive Dysfunction in Mice
https://pubmed.ncbi.nlm.nih.gov/36413...

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
https://pubmed.ncbi.nlm.nih.gov/19414...

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice
https://pubmed.ncbi.nlm.nih.gov/31195...

Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
https://pubmed.ncbi.nlm.nih.gov/15924...

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
https://pubmed.ncbi.nlm.nih.gov/24245...

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
https://pubmed.ncbi.nlm.nih.gov/23066...