Neoatherosclerosis and In stent Restenosis

#neoatherosclerosis #In_stent_restenosis Description at: https://johnsonfrancis.org/profession... Discussion on neoatherosclerosis and in-stent restenosis.
Neointimal proliferation can occur within a coronary stent. Chronic inflammation within the neointima with infiltration of macrophages leads to neoatherosclerosis and result in in-stent restenosis.
Disruption of neoatheroma can cause acute thrombotic occlusion. Hence neoatherosclerosis is a complication of percutaneous coronary intervention and can present with recurrence of angina or acute coronary syndrome.
Occurrence of neoatherosclerosis is earlier in drug eluting stents than in bare metal stents and has a greater prevalence. Late stent thrombosis due to rupture of the plaques with thin fibrous cap is associated with high mortality.
Thus in-stent neoatherosclerosis is an important contributing factor to late vascular complications of very late stent thrombosis and late in-stent restenosis.