Скачать или смотреть Selecting conditioning regimens in elderly patients with hematological malignancies

As the number of elderly patients with hematological malignancies increases, there are more factors that need to be considered before making the decision to undergo allogeneic hematopoietic stem cell transplantation (alloHSCT). In this video, Nico Gagelmann, MD, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, talks on selecting conditioning regimens in elderly patients with hematological malignancies. When choosing a conditioning regimen, it is important to consider the balance between the risk of relapse and the risk of non-relapse mortality (NRM) associated with transplantation. Higher intensity conditioning regimens like myeloablation reduce the risk of relapse and increase the risk of NRM whilst reduced-intensity conditioning (RIC) regimens have the opposite effect. In elderly patients, RIC regimens such as treosulfan-fludarabine are favored as the risk of relapse is of a lower priority than the risk of NRM. This interview took place at the 48th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2022, which was held virtually.