The return of the Ice Bucket Challenge 2022

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ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

”Amyotrophic” comes from the Greek language. "A" means no. "Myo" refers to muscle. "Trophic" means nourishment. So, amyotrophic means "no muscle nourishment,” and when a muscle has no nourishment, it "atrophies" or wastes away.

"Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located.

As this area degenerates, it leads to scarring or hardening ("sclerosis") in the region.

French neurologist Jean-Martin Charcot discovered ALS in 1869. While ALS can affect anyone, anywhere, at any time, there are two different ways cases are categorized.

For about 90% of all cases, there’s no known family history of the disease or presence of a genetic mutation linked to ALS.
For 5-10% of all cases, there’s a known family history of the disease. This is often called familial ALS.
For In families with familial ALS, there is a 50% chance each offspring will inherit the gene mutation and may develop the disease.

For unknown reasons, military veterans are more likely to be diagnosed with the disease than the general public.

A wealth of new scientific understanding about the physiology ALS has occurred in recent years. There are currently four drugs approved by the U.S. FDA to treat ALS: Riluzole, Nuedexta, Radicava and Tiglutik.

Source https://www.als.org/understanding-als...