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When a glass ampoule is opened incorrectly, or if a filter needle is not used during medication preparation, microscopic or even visible glass shards can be drawn into the syringe along with the drug. If these fragments are then injected into the body, they can cause a range of harmful effects depending on their size, number, and location of injection.
At the injection site, glass particles may cause local tissue irritation, inflammation, or damage to blood vessels and surrounding structures. If injected intravenously, the shards can travel through the bloodstream and potentially lodge in small vessels, creating a risk of microemboli. This may result in pain, tissue ischemia, or in severe cases, damage to organs such as the lungs, kidneys, or brain. Over time, retained glass fragments may also provoke foreign body reactions, leading to granuloma formation or chronic inflammation.

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