Studying Aggression in Drosophila (fruit flies)

Drosophila, commonly known as fruit flies, have been used as a model organism for studying aggression due to their simple nervous system and genetic tractability. Aggression in Drosophila is characterized by behaviors such as lunging, chasing, and fighting, which are often triggered by competition for resources such as food, mates, or territory.

Researchers have identified several genes and neural circuits that regulate aggression in Drosophila. For example, the gene fruitless (fru) has been shown to be necessary for male aggression, while the gene serotonin receptor 5-HT1B is involved in regulating aggression in both males and females. Additionally, the neural circuits that control aggression have been mapped, revealing that specific neurons in the brain are responsible for initiating and modulating aggressive behavior.

Studies have also investigated the role of environmental factors in shaping aggression in Drosophila. For example, exposure to high levels of alcohol has been shown to increase aggression in male fruit flies, while social isolation can lead to increased aggression in both males and females.