Why A1C Isn't Enough: Insights from Dr. Ben Bikman with Dr. Ken Berry

In this episode of The Metabolic Classroom, Dr. Ken Berry and Dr. Ben Bikman discussed the critical role of endogenous insulin, the limitations of focusing solely on glucose levels, and the implications of common markers like A1C and uric acid in understanding metabolic health.

Dr. Berry began by highlighting how many primary care physicians misunderstand the function of beta cells in type 2 diabetes, often believing that these cells “burn out” and stop producing insulin. Dr. Bikman clarified that in true type 2 diabetes, beta cells do not fail entirely; instead, insulin production often remains high or slightly decreases, which is still significantly higher than normal.

The problem lies in the body’s insulin resistance, not a lack of insulin production. Dr. Bikman emphasized the importance of measuring fasting insulin levels early in a patient's metabolic health journey, noting that levels above 6 microunits/mL can indicate potential problems.

The conversation then shifted to the A1C test, a common marker used to assess blood glucose levels over time. Dr. Berry and Dr. Bikman discussed the limitations of A1C, particularly how it can be falsely elevated or decreased based on the lifespan of red blood cells. Longer-lived red blood cells can cause a falsely high A1C, even if glucose levels are normal, while short-lived red blood cells can lead to a falsely low A1C in the presence of hyperglycemia. Dr. Bikman suggested that while A1C has value, it should not be the sole marker for assessing metabolic health. He also pointed out that A1C does not account for the glycation caused by other sugars like fructose, which can lead to significant damage not reflected in A1C results.

Dr. Berry raised concerns about the carnivore community, where some individuals see their A1C levels rise despite a healthy diet. Dr. Bikman explained that this could be due to longer-lived red blood cells resulting from a nutrient-rich diet. He recommended the fructosamine test as a better indicator of glucose glycation in these cases. The discussion also touched on the lack of tests for fructose and galactose glycation, leaving healthcare providers blind to the potential damage caused by high fructose intake, especially from fruit juices.

The classroom discussion concluded with an exchange about uric acid, particularly its relationship with fructose metabolism. Dr. Bikman shared insights from his research showing that uric acid, which is produced during fructose metabolism, can contribute to insulin resistance and inflammation. However, he also noted that ketones, produced during a ketogenic diet, can inhibit the inflammation caused by uric acid, providing a potential explanation for why individuals on ketogenic diets may experience improved metabolic health despite elevated uric acid levels.

https://www.insuliniq.com

00:00 - Introduction: Dr. Ken Berry on Insulin and Beta Cells
01:25 - Dr. Ben Bikman on Insulin Resistance and Type 2 Diabetes
03:22 - The Importance of Measuring Fasting Insulin Levels
05:43 - Discussion on LabCorp and Quest Insulin Cutoffs
07:03 - Understanding A1C: What It Measures and Its Limitations
10:18 - The Impact of Red Blood Cell Lifespan on A1C Results
14:42 - The Carnivore Diet and Elevated A1C: A Closer Look
19:01 - Fructosamine Test: An Alternative to A1C for Carnivores
20:30 - The Problem with Fructose Glycation and Lack of Testing
23:00 - Uric Acid as a Proxy for Fructose Glycation
24:44 - The Role of Uric Acid in Insulin Resistance
26:42 - How Ketones Combat Uric Acid-Induced Inflammation
28:00 - Closing Remarks: The Importance of Comprehensive Metabolic Markers

Learn more about Dr. Ken Berry: https://www.drberry.com/about

#InsulinResistance #Type2Diabetes #DrBenBikman #DrKenBerry #A1CTest #FastingInsulin #UricAcid #CarnivoreDiet #Fructose #MetabolicHealth #KetogenicDiet #Inflammation #BetaCells #Endocrinology #BloodGlucose #ProperHumanDiet #HealthLecture #MetabolicClassroom #BiomedicalScience #InsulinIQ

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