Скачать или смотреть #6 Allele-specific expression

I talk about allele-specific expression: why it arises and how it can be
reliably detected.







Sections:





• The biology of allele-specific expression (2:17)


• Detecting allele-specific expression with RNA-seq (7:46)


• Mapping and sequencing biases (16:39)


• The experiment in yeast (19:47)


• Statistical models (21:44)





Links:





• A powerful and flexible statistical framework for testing hypotheses of
allele-specific gene expression from RNA-seq data (http://genome.cshlp.org/content/21/10...)



• Supplemenal information (http://genome.cshlp.org/content/suppl...)





• Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data (https://www.ncbi.nlm.nih.gov/pmc/arti...)


• The talk by John Marioni (http://medias01-web.embl.de/Mediasite...)


• The blog post explaining the RSEM model (https://ro-che.info/articles/2017-01-...)








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