Скачать или смотреть In CF, it’s not just the lungs — pancreas clogged too. 🧬→ ↓ enzymes → ↓ fat abs → vit (A, D, E, K).

UWorld Pediatrics & GI ⚡ | Cystic Fibrosis — when mucus steals your vitamins.

In CF, it’s not just the lungs — your pancreas is clogged too. 🧬
→ ↓ pancreatic enzymes → ↓ fat absorption → ↓ fat-soluble vitamins (A, D, E, K).
And when vitamin K drops, your clotting factors (II, VII, IX, X) go on strike. 😵‍💫

💉 Clinical clues:
• Easy bruising
• Mucosal & GI bleeding
• Epistaxis
• Prolonged PT
• Bleeding after antibiotics (gut flora gone = no K synthesis)

🧩 Other causes: Cholestatic liver disease, biliary atresia, broad-spectrum antibiotics.
🩺 Management: Pancreatic enzyme replacement + fat-soluble vitamin supplementation (ADEK).

So next time your CF patient has nosebleeds or bruises — don’t just blame the mucus, blame the malabsorption. 😷

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