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When living with ME/CFS or Long COVID, even getting out of bed can feel like running a marathon.

In this episode, Haylie Pomroy sits down with Dr. David Systrom, a Harvard physician and Director of the Advanced Cardiopulmonary Exercise Lab at Brigham and Women’s Hospital to talk about exercise intolerance for people with chronic illnesses and why so many patients are left without answers.

Dr. Systrom shares findings from invasive cardiopulmonary exercise testing and explains why traditional tests often miss what patients are actually experiencing. They dig into post-viral illness, mitochondrial dysfunction, dysautonomia, and the promise of clinical trials that could lead to more compassionate and targeted care.

Tune in to the Hope and Help for Fatigue and Chronic Illness Podcast - Advancements in ME/CFS and Long COVID Care.

Key Points:
00:00 Introduction
04:01What iCPET is and how it works.
06:14 Symptoms that led to deeper testing.
09:32 Patient and doctor frustration from repeated negative tests.
11:45 What is mitochondrial dysfunction?
16:37 Inflammation begets mitochondrial dysfunction.
20:41 Gut issues and microbiome leakage.
28:04 How to join clinical trials.
31:32 Treating based on symptom subtypes.
35:16 The long history of underdiagnosing ME/CFS.

Sign up for the COVID-UPP Study:
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If you are interested in joining a Gulf War Illness (GWI) trial, please complete the Recruitment Registry Form.
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Dr. David Systrom, MD. is the Director of the Advanced Cardiopulmonary Exercise Laboratory at Brigham and Women’s Hospital and Assistant Professor at Harvard Medical School. His work focuses on uncovering the mechanisms of exercise intolerance and helping build more precise, effective treatments for patients with ME/CFS and Long COVID.

Want to help advance research in ME/CFS and Long COVID? You may be eligible to join The LIFT Trial and the Mitochondrial Muscle Study.

Reach out to: Johanna Squires, Senior Clinical Trial Coordinator
Email: [email protected]

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com
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