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Histopathology-Fixative & Fixation Introduction,Factors Affecting of Fixative and Types of Fixative by PLUS study IQ simple explanation in hindi

It is a process by which the cells or tissues are fixed in chemical and partly
physical state so that they can withstand subsequent treatment with various
reagents, with minimal distortion of morphology and no decomposition.
OBJECTIVES
After reading this lesson, you will be able to:
state the aims of fixation
explain the principle of fixation
describe the properties and factors affecting fixation
explain types of fixation.
5.2 AIMS OF FIXATION
(a) To preserve the tissues as close to their living state as possible
(b) To prevent autolysis and bacterial attack
(c) To prevent tissues from changing their shape and size during processing
(d) To harden the tissues
(e) To allow clear staining of sections subsequently
(f) To improve the optical differentiation of cells & tissues
5.3 PRINCIPLE OF FIXATION
Fixation results in denaturation and coagulation of protein in the tissues. The
fixatives have a property of forming cross links between proteins, thereby
forming a gel, keeping everything in their in vivo relation to each other.