Multiple sequence alignments 2021

Описание к видео Multiple sequence alignments 2021

Reading: Jin Xiong, Essential Bioinformatics, Ch. 5

0:55 Scoring, Sum of Pairs (SP)
5:40 Dynamic Programming
7:35 Divide and Conquer
10:19 Progressive alignment (I misspoke -- sequence profiles are covered in Gunnar's lecture "Profiles and HMMs" which follows AFTER this one, not before)
18:10 Iterative alignment (PRRN)
21:55 Block-based alignment (DIALIGN)

In Progressive Alignment, step 1 is actually done with a fast empirical method of Wilbur & Lipman, based on k-tuples:
https://www.ncbi.nlm.nih.gov/pmc/arti...

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