Скачать или смотреть Not all Biological Age Tests are Created Equal; Don’t Waste Your Money

Biological or Epigenetic Age Tests are very much in vogue at the moment, so what are the and what do they tell us? Also, they do not all test the same thing and they are not all created equal, you could be paying for a very inaccurate test.

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Epigenetics is the science of how our DNA is controlled and how it’s affected by external factors; these external factors affect our health-span and lifespan. Genetics is fixed from birth; we get our genes from our parents and they define us as being male or female, they control our eye colour, height etc. This is what is measured by companies such as 23andMe. We all share more than 99% of our DNA, however the remaining 1% varies from person to person; this is what makes us unique. • Epigenetics looks into the dynamic changes in our gene function overtime, changes that don’t involve a change in the underlying DNA sequence; these changes are influenced by external factors. So, how much can these external ‘epigenetic’ factors actually affect out lifespan and health-span?
• Someone who is at high risk of heart disease from a genetic predisposition, so there is a family history of heart disease, may have four times the chance of developing heart disease because it is in their genes; that is obviously bad
• But compare that to someone who has a low risk of heart disease from a genetic pre-disposition, but is affected by external environmental and lifestyle factors, the risk to them is 5,000 fold, so 5,000 times more chance of getting heart disease because of the environment or the life choices they made.
• So, there is a lot more risk from factors that are under our control, than from our genes,
• As David Sinclair says, ‘Only 20% of longevity is genetic, the rest is up to you, what will you do today? So, identical twins have the same DNA, but through lifestyle choices may well have vastly different health outcomes by the time they reach middle-age.
• Biological age testing allows us to read our epigenetic markers, markers that we can influence through changes to our lifestyle
• Epigenetic markers change every time one of our cells divides, and even when our cells are not dividing, changes are still taking place to our epigenetic markers
• We can affect, through lifestyle, the way that these markers change and through DNA methylation testing we can monitor our progress, either good or bad. It is not easy to do the right thing and there is no magic pill, targeted supplementation is only a small part of the answer. So, why should we check our Biological age?
• Our Epigenetic age is a much better measure of our health, well-being, lifespan and health-span than our chronological age
• Knowing our epigenetic or biological age allows ‘us’ - you and me - to move our healthcare needs from being reactive to being proactive;
We can become citizen scientists; we can take responsibility for our own longevity by measuring our health objectively at the molecular level
• And once we know our Epigenetic age, we can take measures to adjust it if necessary, I am guessing no matter what your biological age is, you would like to see it lower?
• David Sinclair often talks about gateway issues such as being pre-diabetic or having elevated blood pressure, these very rarely stand-alone forever, they usually open the door to type 2 diabetes and hypertension, which in turn lowers our bodies defenses and opens us up to even more serious diseases. There are now many companies that measure telomere lengths to predict epigenetic age, this is Dr Tom Stubbs, the CEO of Chronomics a company that conducts DNA methylation tests. There are some issues with the accuracy of telomere length testing.
So, there are upwards of 20 million markers available to build models that can more accurately predict age, so there is a lot more information available than the one marker that is used when estimating age using telomeres.
#epigenetics #Livelonger #DavidSinclair
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