Episode 47: LDL on keto, what is a lean mass hyper responder?

Dr. Nick Norwitz (‪@nicknorwitzPhD‬ ) discusses the relationship between sweeteners, metabolic dysfunction, and insulin resistance. He highlights a study that tested the hypothesis that uncoupling sweet taste from calories would lead to metabolic dysfunction. The study found that the combination of sucralose and maltodextrin induced insulin resistance, while sucralose alone did not. Dr. Norwitz shares his personal journey with ulcerative colitis and how a ketogenic diet transformed his health. He emphasizes the complexity of metabolism and the need for individualized approaches to achieve metabolic health. The conversation in this section covers two main themes: the importance of authenticity in content creation and the lean mass hyper responder phenotype in ketogenic diets. The speakers discuss the lack of funding and incentive structure for research on low carbohydrate diets, highlighting the importance of self-funded initiatives. They also emphasize the need for authenticity in media and the importance of building trust with the audience. The lean mass hyper responder phenotype is explained as a triad of high LDL cholesterol, high HDL cholesterol, and low triglycerides, which tends to occur in lean and athletic individuals on a low carb diet. The lipid energy model is proposed as a mechanism to explain this phenomenon. The conversation explores the idea that calories are not the sole driver of obesity, but rather fuel partitioning plays a significant role. The energy equation (energy in minus energy out equals energy stored) does not imply causation. The focus should be on understanding the factors that influence fuel partitioning, such as hormonal factors and other physiological processes. The conventional idea that obesity is solely a calorie problem is misleading and does not align with the available data. The conversation also touches on the topic of lipoproteins and the need for more research to understand the risk associated with high LDL levels.

Chapters

00:00 - Introduction and Background
08:08 - Dr. Norwitz's Personal Journey with Ulcerative Colitis
15:29 - The Lean Mass Hyper Responder Phenotype
28:28 - Exploring the Role of Lipoproteins and Fuel Partitioning
33:47- The Complex Relationship Between BMI, Obesity, and Calorie Intake
45:24 - Shifting the Mindset: From Calories to Fuel Partitioning
53:40 - The Unknown Risk of High LDL Cholesterol Levels
01:04:15 - The Importance of Individualized Approaches to Managing Lipid Levels
01:05:50 - The Impact of Sweeteners on Metabolic Health
01:08:05 - The Surprising Findings of a Study on Sweeteners
01:09:33 - The Potential Benefits of Allulose
01:14:00 - The Fascinating Mechanisms of Protein Metabolism

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