Скачать или смотреть Rh(I)-Catalyzed Allenic Pauson-Khand Reaction

This approach allows rapid access to Tg analogues with variations to the carbocyclic core as well as stereochemical isomers not previously accessible via synthesis. The enantioselectivity of the APKR is greatly increased by substituting the allene with a chloroacetate group.

The intramolecular Rh(I)-catalyzed allenic Pauson–Khand reaction
(APKR) is a powerful synthetic method for constructing ring-fused
cyclopentenones. At that time, there were two independent reports of allenes being used in the PKR–only Aumann’s demonstrated the feasibility of an
intermolecular Fe(0)-catalyzed process.
In 1994, Narasaka demonstrated 3 examples of an intramolecular APKR using allenyl sulfides and an iron carbonyl complex.

In 1995, Corey et al. reported a successful intramolecular APKR
reaction of unfunctionalized allenes using stoichiometric Mo(CO)6–a transition metal complex that had recently been reported by Jeong for the enyne PKR.