How Tysabri (natalizumab) works in Multiple Sclerosis

In this vid, I explain the mechanism of action of Tysabri (natalizumab) in relapsing Multiple Sclerosis, In broad strokes, the naughty autoreactive immune cells in the blood stream cross over the blood brain barrier where they gain access to the central compartment and attack brain and spinal cord tissue!

Considering the "three little pigs" story, we can think of the normal blood brain barrier as the "straw house." It's very easy for cells to cross the barrier!

If we add tysabri, we turn the "straw house" into the "brick house" - we create the great wall of china and allow NO cells to traffic across the blood brain barrier. Therefore those naughty cells that would attack brain IF they could gain access are kept out of the central compartment.

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NOTE: Make sure to talk to your provider before ANY treatment decision. We hope to educate, empower and energize those impacted by Multiple Sclerosis. This channel consists of a collection of formal lectures and informal video clips about MS to help education others. These videos do not provide medical advice and are for informational/educational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos. They are just to help educate you about the condition guys!