Teasing out the secrets of subtle protein dynamics - Helen Ginn

Structural biology experiments are focusing increasingly with the small, subtle motions underpinning protein function. Our collective understanding of how these subtle motions translate to functional impact is limited, and this is hampering efforts in protein engineering and drug development. The
Protein Machinists’ lab develops conceptual frameworks for defining, modelling and navigating the protein’s conformational space, focusing on the representation of protein entities (RoPE). The first tool of RoPE is a simple and powerful visualisation of conformational space from experimental data,
and how this space can be used to drive protein refinement against electron density. This talk will illustrate with examples how these tools help find the narrative in modern multi-dataset experiments.