Скачать или смотреть From Lab to Production- Scaling Bioprocesses the Smart Way

Presented By: Christian Witz, PhD

Speaker Biography: Christian Witz completed his PhD in the group of Prof. Khinast at Graz University of Technology, specializing in multiphase reactor simulation using the lattice Boltzmann method. Following his doctorate, he founded the Computational Bioprocess Engineering group at the institute, focusing on the development, validation, and integration of highly efficient GPU-accelerated algorithms to simulate physical processes inside bioreactors and similar devices. This in-house code base became the foundation for SimVantage, a spin-off that provides cloud-based simulation software and consulting services for stirred and aerated reactors. Recently, SimVantage was honored with Austria’s most prestigious award for applied research, the Houska Prize.

Webinar: From Lab to Production- Scaling Bioprocesses the Smart Way

Webinar Abstract: Scaling a bioprocess from laboratory experiments to full-scale production is a complex challenge that requires a deep understanding of process dynamics and equipment differences. Traditional scale-up approaches often rely on empirical correlations and trial-and-error, leading to inefficiencies, high costs, and unpredictable performance. In this talk, we introduce computational fluid dynamics (CFD) as a tool for scale-up. SimVantage, a cloud-based simulation platform that enhances bioprocess development by integrating mechanistic modeling with experimental data will be shown as an example for a modern and easy-to-use CFD program. The SimVantage scaling tool enables a systematic approach to scale-up by predicting process behavior across different scales, identifying potential bottlenecks, and optimizing critical parameters before experimental validation. Attendees will learn how mechanistic models can be used to capture key bioprocess characteristics, such as mass transfer, metabolic activity, and mixing effects, and how these models can be leveraged to de-risk scale-up decisions. We will also discuss case studies demonstrating how SimVantage improves process efficiency, accelerates development timelines, and reduces the need for extensive laboratory experimentation. By the end of this session, participants will have a clearer understanding of how simulation-driven scale-up strategies can enhance robustness and reproducibility in bioprocessing.


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