Скачать или смотреть Tumor Suppressor Genes Tumor Markers ; VRB, P53, DCC, PTEN, WT1, NF1, APC, BRCA 1&2

Tumor suppressor genes act as cellular guardians that help regulate cell division, repair DNA mistakes, and ensure cells don't grow uncontrollably. When these genes are mutated or inactivated, it can lead to various types of cancer. Here's a concise breakdown of the ones you mentioned:

VRB (RB1): The retinoblastoma gene is critical for controlling the cell cycle. Loss or mutation is linked to retinoblastoma and osteosarcoma.

P53 (TP53): Known as the “guardian of the genome,” this gene helps maintain DNA integrity. Mutations in TP53 are common across a wide spectrum of cancers, including breast, lung, and colon.

DCC: Stands for Deleted in Colorectal Cancer. It plays a role in cell adhesion and signaling, and its loss is commonly seen in colorectal tumors.

PTEN: A phosphatase involved in cellular growth suppression. Its mutation is implicated in glioblastomas, endometrial, and prostate cancers.

WT1: Essential in kidney and gonadal development, WT1 mutations are primarily associated with Wilms tumor, a pediatric kidney cancer.

NF1: Mutations in this gene cause neurofibromatosis type 1 and predispose individuals to nerve sheath tumors and certain brain tumors.

APC: A regulator of the Wnt signaling pathway. Mutations in APC cause familial adenomatous polyposis and increase colorectal cancer risk.

BRCA1 & BRCA2: These genes are pivotal in DNA repair mechanisms. Inherited mutations elevate the risk for breast, ovarian, prostate, and pancreatic cancers.

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