How Does Peyote Work? | The Science of Mescaline

Peyote contains a compound called Mescaline, very similar to LSD. It acts on the Serotonin receptors in your central nervous system, leading to a variety of physiological effects!

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What Is Peyote? A species of hallucinogenic cactus. It is found in the Chihuahuan desert around the border along the south of north america and northern Mexico. Peyote is generally illegal in most places, although there is an exemption for certain sacred and religious ceremonies.

How Does Peyote Work? Once a person ingests it, the body absorbs mescaline rather quickly. The effects may begin in under an hour and can last for around 12 hours.

Mescaline interacts with 5-HT2 receptors in the brain, which are also the targets of other classic hallucinogens such as LSD and psilocybin mushrooms. They are likely responsible for the “trip” a person experiences when using these substances.

What are the effects of Peyote? Vivid hallucinations, Visual Distortion, Auditory DIstortion, Synthesesia, and even time distortion. Peyote triggers an altered state of consciousness often described as happy, positive, enjoyable, illuminating, feeling like you are in a dream-like state. This can last for around 12 hours. As the body breaks down the mescaline, the effects wear off.

What are the risks associated with Peyote? Vomiting, headache, anxiety, or simply a bad trip. If you don’t feel safe and comfortable, a mescaline trip can be confusing & scary.
A good trip can be pleasant and amusing, but if you start to panic, bad trips can be terrifying. Overdosing on peyote is unlikely, although it can happen. Treatment generally involves hydration therapy to replace fluid lost from vomiting.

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00:00 Peyote Mescaline Intro
00:40 What is Peyote?
01:15 How Does Peyote Work?
02:10 The Effects of Peyote
03:08 The Risks Associated with Peyote
04:11 Peyote Conclusion

Mescaline Pharmacology: https://www.ncbi.nlm.nih.gov/pmc/arti...

Study comparing LSD, Mescaline and Psilocybin: https://clinicaltrials.gov/ct2/show/N...

Mescaline in the CNS: https://www.ncbi.nlm.nih.gov/pmc/arti...