Скачать или смотреть Robert Last - Evolution of metabolic diversity in tomato and its relatives

Robert Last
Michigan State University, Lansing, United States of America.
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From the tip of the trichome to the root of the matter: evolution of metabolic diversity in tomato and its relatives
​ Research in the Last group focuses on specialized metabolism in glandular trichomes and roots of tomato and other plants in the Solanaceae. Acylsugars – relatively simple metabolites typically based on sucrose, glucose or inositol and C2 to C12 acylesters – are most extensively characterized from the tip cell of the long hairs of domesticated and wild tomato. Despite being derived from simple chemical building blocks, tremendous variation in acylsugar structures is observed within and across species. Some of the changes in products and enzymatic activities have occurred over remarkably short evolutionary timeframes. The talk will document ‘recruitment’ of enzymes of central metabolism to acylsugar biosynthesis, as well as studies of BAHD acyltransferase evolution. I will emphasize how comparative biochemistry led to insights into how gene duplication, neofunctionalization and gene loss contributed to the impressive acylsugar diversity observed in domesticated and wild tomato species. Work towards understanding the evolutionary history of this metabolic network over tens of millions of years of evolution of the Solanaceae will be described. I will also discuss recent results characterizing root acylsugars in tomato, with preliminary data indicating that this biosynthetic pathway is distinct from that in the trichome.

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