The Science of DLG4-SHINE: "Novel Mouse Model of SHINE Syndrome and What it Can Teach Us."

In the second webinar of the The Science of DLG4-SHINE seminar series Dr. John Hogenesch’s lab at Cincinnati Children’s Hospital present their groundbreaking work on sleep and circadian rhythm disruption in SHINE Syndrome, using a mouse model.
SHINE Syndrome, like many genetic disorders such as Angelman’s and Rett syndrome, is associated with significant sleep issues. The webinar discusses how mutations in the DLG4 gene, which is rhythmically expressed and affects the body's molecular clock, contribute to sleep disturbances.
The team has developed a CRISPR-generated mouse model which allows researchers to investigate sleep and various other aspects of the disorder and how these findings may translate into therapeutic interventions.
The presentation is offered in simple, easy to understand, language for the patient community and is followed by a short period of question and answer.