Скачать или смотреть COVID-19 and Ivermectin - A Scientific Approach

This is the eleventh video in the series of SARS-CoV-2 pandemic.
It comprehensively describes the pharmacology, molecular biology, biochemistry and plausible use of Ivermectin in COVID-19 patients.
Initially, researchers working on the development of ivermectin believed that it blocked neurotransmitters, acting on GABA-gated Cl− channels, exhibiting potent disruption at GABA receptors in invertebrates and mammals. GABA is recognised as the primary inhibitory neurotransmitter in the somatic neuromuscular system of nematodes. Subsequently, they discovered that it was in fact glutamate-gated Cl− channels (GUCl−) that were the target of ivermectin and related drugs. This discovery opened up a completely new spectrum of possibilities, as these channels, although playing fundamental roles in nematodes and insects, are not accessible in vertebrates. Ivermectin, while paralyzing body-wall and pharyngeal muscle in nematodes has no such impact in mammals, as it cannot cross the blood-brain barrier into the mammalian Central Nervous System, where GABA receptors are located. For a long time, it was believed that ivermectin was contra-indicated in children under the age of five or who weighed less than 5 kg, as there was a fear of neurotoxicity, the drug possibly being able to cross the as yet not fully developed blood/brain barrier. However, evidence has emerged that is probably not the case.
Originally identified as an inhibitor of interaction between the human immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the importin (IMP) α/β1 heterodimer responsible for IN nuclear import, Ivermectin has since been confirmed to inhibit IN nuclear import and HIV-1 replication. Other actions of ivermectin have been reported, but ivermectin has been shown to inhibit nuclear import of host (eg. viral proteins, including simian virus SV40 large tumour antigen (T-ag) and dengue virus (DENV) non-structural protein 5. Importantly, it has been demonstrated to limit infection by RNA viruses such as DENV 1-4, West Nile Virus, Venezuelan equine encephalitis virus (VEEV) and influenza, with this broad spectrum activity believed to be due to the reliance by many different RNA viruses on IMPα/β1 during infection.

Links of Research Papers -
1. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.
https://www.sciencedirect.com/science...

2. Ivermectin, ‘Wonder drug’ from Japan: the human use perspective.
https://www.ncbi.nlm.nih.gov/pmc/arti...

Link of My Facebook Page -   / rahulsadvancedbiology  

COVID-19 Video Links -
1. Coronavirus (COVID-19) - Virology and Outbreak -    • SARS-CoV-2 - Virology and Outbreak  

2. Coronavirus (COVID-19) - ACE and ARB Dilemma -
   • COVID-19 - ACE and ARB Dilemma  

3. Coronavirus (COVID-19) - Hydroxychloroquine - Hype or Real -
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4. Coronavirus (COVID-19) - Treatment - REMDESIVIR - Hype or Real -
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5. Coronavirus (COVID-19) - Treatment - Chloroquine + Azithromycin - Hype or Real Part II
   • COVID-19 and Chloroquine + Azithromycin - ...  

6. Coronavirus (COVID 19) -Treatment/Cure - Chloroquine + Azithromycin - Hype or Real
   • Coronavirus (COVID 19) and Chloroquine + A...  

7. Coronavirus (COVID-19) - Treatment/Cure - Tocilizumab - Hype or Real
   • COVID-19 and Tocilizumab - A Scientific Ap...  

8. Coronavirus (COVID-19) - Why Are Men More Affected Than Women? - Pathogenesis and Receptor Binding
   • COVID-19 - Why Are Men More Affected Than ...  

9. Coronavirus (COVID-19) - Treatment/Cure - RNA Dependent RNA Polymerase Analysis
   • COVID-19 - RNA Dependent RNA Polymerase An...  

10. COVID-19 and Diabetes - Treatment/Cure - DPP4 Inhibitors - Hype or Real
   • SARS-CoV-2 and Diabetes - DPP4 Inhibitors ...