Activated JAK-STAT signaling co-operates with HOXA9 to drive leukaemia

Описание к видео Activated JAK-STAT signaling co-operates with HOXA9 to drive leukaemia

Dr de Bock talks to ecancertv at EHA 2016 about the role of a conserved gene cluster called HOXA, and it's co-operative role in driving T-cell acute lymphoblastic leukaemia.

He describes how HOXA mutations, especially HOXA9, are often concurrent with mutations in the cell cycle regulatory JAK pathway, and that the two of them together are strong drivers of oncogenesis.

Dr de Bock also discusses how these pathways might be identified and regulated, giving example of the resequencing in patients that determined this genotype.

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