19. Urokinase Plasminogen Activator-Targeted Oncolytic Newcastle Disease Virus for Canine Tumors

Phase I/II Trial of Urokinase Plasminogen Activator-Targeted Oncolytic Newcastle Disease Virus for Canine Intracranial Tumors

https://pubmed.ncbi.nlm.nih.gov/38339...

What is the hypothesized reason that cerebral edema was observed as an adverse event?
A. Infection of platelets.
B. An immune-mediated event.
C. A potent viral-induced, local inflammatory response.
D. All of the above

How was the presence of rLAS-uPA in the brain tumors confirmed?
A. Plaque neutralization assay B. ELISA C. Quantitative RT-PCR D. MRI

What percentage of dogs experienced durable MRI-derived volumetric tumor reductions meeting the criteria for partial response?
A. 2% B. 5% C. 10% D. 20%

Which of the following tumor types was NOT included in the study?
A. Meningiomas B. Pituitary Tumors C. Neuroepithelial neoplasms D. Cranial nerve tumors

Why was the T2 total tumor volume (TTV) method used to evaluate the anti-tumor effects of the viral infusions?
A. It is more accurate than other methods. B. Not all the tumors were contrast-enhancing C. It is the only method available D. It is the cheapest method