CRP Test | C-Reacted Protein (CRP) Test | CRP Test In hindi | High सीआरपी लेवल का क्या मतलब होता है

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What is CRP test
Normal value of CRP
How to do CRP test
CRP test in hindi

Acute-phase protein (Acute Phase Reactants)

Acute-phase proteins are raised in inflammatory conditions.
When there is an increase in an acute phase protein called positive acute-phase protein.
In the case of a decrease in the acute phase protein, it is called negative phase protein.
The acute phase proteins (positive) are proteins whose concentration increases in the plasma, and after the disease episode is over, it decreases and may become normal.
C-Reactive Protein (CRP)
Sample
The venous blood of the patient is needed to prepare the serum.
A fasting sample is preferred.
A random sample can be taken.
Analyze the fresh sample.
Or can store at 4 °C for 72 hours.
At -20 °C for six months.
Indications
Advised in bacterial infection.
It is advised in rheumatic fever.
It is advised in rheumatoid arthritis.
It may be advised after the surgery.
Precautions
This may be raised in cigarette smoking.
Avoid hemolysed and lipemic samples.
Raised values are seen in hypertension, diabetes mellitus, metabolic syndrome, gingivitis, and bronchitis.
Decreased values have seen weight loss, moderate consumption of alcohol, and exercise.
Estrogens and progesterone increase value.
Niacin, statin, and fibrates decrease value.
Pathophysiology
Definition:
CRP is produced in the liver, and its name is derived from its reaction with streptococcal capsular polysaccharides.
CRP level supporting bacterial endocarditis, appendicitis, and active collagen diseases was 10 mg/L.

There are changes in the plasma protein in response to:
Acute illness.
Trauma.
Necrosis.
Infarction.
Burns.
Chemical injury.
Malignant tumors.
The acute reaction proteins pattern is also called:
Acute inflammatory response pattern.
Acute stress pattern.
Acute-phase protein pattern.
CRP is found in the Gamma-region band on serum electrophoresis.
CRP is absent from the healthy person.
CRP increased after any injury (trauma, bacterial infection, surgery, neoplasm, and inflammation) to 100 times.
CRP was given the name in 1941 that it is protein.
This is a nonspecific acute-phase protein.
CRP starts rising after 4 to 6 hours of the infection, while other proteins rise after 12 to 36 hours of the initiating cause.
CRP is functionally analogous to IgG, except it is not antigen-specific.
This protein is synthesized in the liver and released into blood circulation after tissue injury in a few hours.
The synthesis of the CRP is initiated by:
Antigen immune complexes.
Bacterial infection.
Fungal infection.
Trauma or tissue injury.
High-sensitivity CRP (hs-CRP):
It detects the lower level of CRP, which is important to find the risk of cardiac events.
The sensitivity is 0.01 mg/dL.
In the case of raised hs-CRP, follow-up serial measurements are needed.
hs-CRP is useful for the risk of developing acute myocardial infarction with a history of the acute coronary syndrome.
Value ≥1.0 mg/L indicates subclinical infection/inflammation; this needs to repeat the test in 3 to 4 weeks.

CRP vs. ESR:
More sensitive and rapidly responding than the ESR.
Other physiologic factors influence ESR, but CRP does not.

The Raised Level Is Seen In:
Soft tissue Trauma.
Infection.
Tissue necrosis.
Patients with Rheumatoid arthritis.
In Rheumatic fever.
Patients with systemic lupus erythematosus.
Patient with pneumonia.
Patient with malignancies.
In pregnant ladies.
Pulmonary tuberculosis.
Urinary tract infection.
Myocardial infarction.
Vasculitis syndrome.
Bacterial meningitis.

Decreased CRP Level Is Seen In:
This may be seen in the moderate use of alcohol.l
In weight loss.
Excessive exercise.
Medicine like Niacin, and a statin.