Скачать или смотреть SPL | Prof. Nir Gov | Emergent oscillations during cellular directional decision-making on junctions

SPL | Prof. Nir Gov | Emergent oscillations during cellular directional decision-making on junctions

Speaker: Professor Nir Gov (Weizmann Institute of Science)
Date: 21st Sept 2023 - 11:00 to 12:00

Title: Emergent oscillations during cellular directional decision-making on junctions

Event: (SPL) New statistical physics in living matter: non-equilibrium states under adaptive control

Abstract: Motile cells inside living tissues often encounter junctions, where their path branches into several alternative directions of migration. We present a theoretical model of cellular polarization for cells migrating along one-dimensional lines, arriving at a symmetric Y-junction and extending protrusions along the different paths that emanate from the junction. The model predicts the spontaneous emergence of deterministic oscillations between competing protrusions, whereby cellular polarization and growth alternate between the competing protrusions. The oscillations are modified by cellular noise but remain a dominant feature which affects the time it takes the cell to migrate across the junction. These predicted oscillations in the cellular polarization during the directional decision-making process at the junction are found experimentally for two different cell types, noncancerous endothelial and cancerous glioma cells, migrating on the patterned network of thin adhesive lanes with junctions.