Скачать или смотреть Psilocybin Dosage, Age, & Neuroticism Predict Mystical vs Challenging Trips (Ko et al., 2023)

Disclaimer: This is AI-generated content guided and reviewed by a PhD Biomedical Science and Neuroscience researcher and professor (Brenna Bray, PhD).

I. Study Overview
This video reviews a 2023 analysis of a clinical trial.
Researchers examined 89 volunteers in a controlled setting.
Participants received placebo, 10 mg, or 25 mg of psilocybin.
The goal was to predict mystical and challenging effects.

II. Key Findings on Dosage
Dosage was the strongest predictor of experience intensity.
Higher doses increased both mystical and challenging states.
The 25 mg dose resulted in significantly higher intensity.
Challenging effects rose more steeply with dose than mystical.

III. How Age Influences the Experience
Age was found to be a protective factor against challenging trips.
Older participants reported lower intensity of ego dissolution.
This may result from better coping skills developed over time.
Age did not significantly correlate with mystical intensity.

IV. The Role of Personality Traits
Most personality traits did not predict the nature of the trip.
Openness to experience showed no correlation with outcomes here.
Neuroticism correlated with challenging trips at 25 mg doses.
Neuroticism may help identify those at risk for difficult trips.

V. What Did Not Predict Outcomes
Biological sex did not predict mystical or challenging outcomes.
Prior use of psychedelics did not influence the intensity.
Positive or negative affect before dosing did not predict them.

VI. Study Limitations and Future Research
The study used a post-hoc design not originally meant for this.
Findings apply to healthy volunteers and may not fit patients.
Future research could use larger datasets or citizen science.

VII. Additional Resource Support
See NourishED RFI's NotebookLM Resource Support Page.
https://notebooklm.google.com/noteboo...

VIII. Source
Ko, K., Carter, B., Cleare, A. J., & Rucker, J. J. (2023). Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis. Neuropsychiatric Disease and Treatment, 19, 2105–2113.

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