Why and where do senescent cells form?

Cellular senescence is one of the nine hallmarks of aging. The prevalence seems to increase with age and may even enhance the aging process. But how much evidence is there to support this? Why do we need to identify senescent cells? And how can we identify senescent cells - where do they form? Well, in this video we will touch on all of these questions as we discuss one of my FAVOURITE topics cellular senescence – especially because this article came out recently that has developed a new genetic tool to identify potentially a different flavour of senescent cells – is their clearance also beneficial – well, you’ll know the answer by the end of the video.

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TIMESTAMPS:
Intro - 00:00
Cellular senescence and aging - 00:45
Markers of senescence (p16 vs. p21) - 03:00
New model to find senescent cells - 05:30
Removal of p21-High cells beneficial? - 08:00
Thoughts - 09:00

REFERENCES:
Wang, B., Wang, L., Gasek, N.S. et al. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging 1, 962–973 (2021). https://doi.org/10.1038/s43587-021-00...
Gasek, N.S., Kuchel, G.A., Kirkland, J.L. et al. Strategies for targeting senescent cells in human disease. Nat Aging 1, 870–879 (2021). https://doi.org/10.1038/s43587-021-00...
Baker, D., Wijshake, T., Tchkonia, T. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011). https://doi.org/10.1038/nature10600

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