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A very large 2021 systematic review and meta-analysis, encompassing nearly 1.2 million participants across different studies, found that high (versus low) dietary ALA intake was associated with a 10% reduced risk of death from all causes, an 11% reduced risk of death from coronary heart disease, and an 8% reduced risk of death from cardiovascular disease. Analyzed another way, every 1 g daily increase in ALA intake (about the same as a half-ounce of walnut, or one tablespoon of canola oil) was associated with a 5% drop in both cardiovascular disease mortality and all-cause mortality. DOI: 10.1136/bmj.n2213

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