What Is Small Fiber Neuropathy?

Small fiber neuropathy is a problem with the thin, sensory nerves that do not have a protective covering. These nerves are responsible for sensing temperature and pain, and their dysfunction can be tested using a pinprick. There is typically an overlap between the sensory changes in small fiber neuropathy and autonomic dysfunction, which is particularly relevant when considering conditions like postural orthostatic tachycardia syndrome (POTS) where there is pooling of blood in the legs.

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