Match Analysis of High LDL on Keto – Matthew Budoff –

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Dr. Matthew Budoff presented the #CoSci keynote on the use of CT angiography to measure atherosclerotic plaque and evaluate the effects of a ketogenic diet on cardiovascular health. He introduced a study involving 100 metabolically healthy participants on a ketogenic diet with extraordinary high levels of LDL. 80 of the participants, both Lean Mass Hyper-Responders (LMHR) and borderline LMHR, exhibited increases in LDL but no corresponding increase in atherosclerotic plaque compared to a matched control group (n=80, Miami Heart) with much lower LDL levels. The study aimed to determine if a high LDL level induced by a ketogenic diet is associated with an increased risk of atherosclerosis. Preliminary results showed no significant differences in plaque levels between the ketogenic group and the control group, suggesting that high LDL levels induced by diet may not pose the same risk as high LDL levels in those of poor metabolic health or genetic abnormalities. These findings are preliminary and research is ongoing.

0:00 - Introduction of Keynote Speaker Dr. Matt Budoff
0:21 - Overview of the Presentation Topic
0:28 - Introduction of CT Angiography Tool
1:19 - Details on the Study and its Participants
2:15 - Exploration of LDL Changes and Keto Diet Impacts
4:00 - Comparisons with Population-Based Study
5:27 - Initial Results on Plaque Levels
6:54 - Discussion on LDL Levels and Plaque Correlation
8:12 - Theoretical Insights and Previous Research References
10:27 - Conclusions Drawn from the Study
11:06 - Invitation for Questions and Answers
19:13 - Additional Discussion on CAC Scores and Their Implications
24:28 - Personal Insights and Experiences with Low-Carb Diets and Patient Treatment
30:19 - Closing Remarks and Audience Appreciation