Investigating site-specific acetylation of ubiquitin & suitability of surrogates by GCE

Описание к видео Investigating site-specific acetylation of ubiquitin & suitability of surrogates by GCE

Talk given by Simon Kienle (University of Konstanz) as part of the International GCE Webinar series. Live talk given on June 20th, 2024.

Covalent attachment of ubiquitin (Ub) to proteins is a highly versatile posttranslational modification. Moreover, Ub is not only a modifier but itself is modified by e.g. phosphorylation and lysine acetylation. However, the functional consequences of Ub acetylation are poorly understood. In this work we comprehensive characterized all seven possible mono-acetylated Ub variants on a biochemical, structural and interactome level. This study also allowed us to assess the suitability of acetylation surrogates in their ability to mimic all aspects of lysine acetylation.

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