Ozempic and Wegovy Linked to Rare Blindness Condition: What You Need to Know
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Recently published in the JAMA Ophthalmology journal, the study by Hathaway and colleagues found an association between semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy (NAION). This retrospective, matched cohort study analyzed existing data, comparing individuals exposed to semaglutide for diabetes or obesity management with those who were not. Participants were matched based on characteristics like age, sex, and medical conditions to ensure comparability, then checked for NAION development.
Key findings revealed that patients with type 2 diabetes on semaglutide had a 4.28 times greater risk of developing NAION compared to those not on the drug, while patients with obesity had a 7.64 times greater risk.
The study was well-conducted for an observational study, with efforts to match individuals and account for confounding factors. However, it had limitations. The observational nature shows an association but does not prove causation. The confidence intervals are broad, meaning there's significant uncertainty in the actual risk. NAION is rare, with 2-10 cases per 100,000 people annually. Its development mechanisms are not well understood, though it may be linked to poor blood flow and conditions like diabetes, high blood pressure, and sleep apnea. The study did not control for the severity of diabetes or obesity, which could influence the risk of NAION. Sicker patients are more likely to be prescribed semaglutide, possibly skewing the results.
So, are you going to go blind by taking semaglutide? Likely not. While the study is noteworthy, many questions remain unanswered, and more data is needed. Robust randomized controlled trials have not shown this side effect.
Thanks for watching and always remember: small tweaks lead to massive peaks!
Dr. Dan
References
Hathaway JT, Shah MP, Hathaway DB, et al. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide. JAMA Ophthalmol. Published online July 03, 2024. doi:10.1001/jamaophthalmol.2024.2296
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Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician.
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