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This video covers MOE applications for analyzing an Ab-Ag complex to identify CDR residue mutations that improve solubility, reduce liabilities whilst maintaining affinity.

0:30 Loading a PDB complex
1:32 Structure preparation with QuickPrep
3:46 Inspecting sequences with the Sequence Editor
4:52 Annotating the antibody
6:10 Controlling the Ag with the System Manager
7:45 Analyzing key interactions using Protein Contacts
11:40 Analyzing Protein Properties using Surfaces
13:55 Calculating Protein Patches
15:33 Analyzing patches using Protein Patch Analyzer
18:11 Calculating Protein Properties
24:02 Virtual mutagenesis using the Protein Builder
27:04 Virtual mutagenesis using Protein Design
32:29 Analyzing mutants using the Database Browser
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