Скачать или смотреть The rationale behind CSF-based liquid biopsies in brain tumors

Stephen Bagley, MD, MSCE, University of Pennsylvania, Philadelphia, PA, comments on the potential of using cerebrospinal fluid (CSF) for liquid biopsies in patients with brain tumors. CSF is in closer proximity to the tumor and may contain higher levels of tumor-derived DNA. Studies have shown that approximately half of patients with gliomas have detectable tumor somatic mutations in their spinal fluid, which could be useful for identifying tumor activity and guiding therapy. However, a larger prospective clinical study is needed to determine the impact of CSF liquid biopsies on clinical management and to establish its routine use in practice. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).

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