Скачать или смотреть 🧠 Groundbreaking Study Reveals Why Women Ruminate More – And It’s in Their RNA

A Mount Sinai-led study published in Science Advances has uncovered a sex-specific RNA molecule (LINC00473) that shapes how female brains process past mistakes and regret—potentially explaining why women are twice as likely to develop depression. Here’s what the research reveals:

🔬 Key Findings:
✔️ RNA link to depression: LINC00473 levels are lower in depressed women’s prefrontal cortex
✔️ Female-specific effects: Boosting this RNA in mice increased sensitivity to regret/sunk costs – but only in females
✔️ Decision-making split: Women’s brains re-evaluate past choices differently than men’s
✔️ New treatment target: Could lead to sex-specific therapies for rumination-based depression

💡 Why This Matters:

Explains why women dwell on regrets more than men

Reveals a biological basis for sex differences in mood disorders

Opens door for RNA-based drugs or brain stimulation therapies

🧩 The Bigger Picture:
"Regret isn’t always bad—it can fuel learning and resilience," says lead author Dr. Brian Sweis. But when amplified by stress, it may spiral into depression. This study bridges neuroscience, psychology, and psychiatry to rethink mental health treatment.

📜 Study: Science Advances (DOI: 10.1126/sciadv.adr3228)

#Neuroscience #DepressionResearch #GenderMedicine #RNA #MentalHealth

💬 Should depression treatments be sex-specific?
[♀️] Yes – biology matters!
[⚥] No – focus on symptoms, not sex

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