Pathology Central Key Concepts: p53

Hey there! Where are you studying medicine? Please put comment below... trying to get a feeling for the breadth of this community!

They don't call p53 the "guardian of the genome" for nothing! This video covers how p53 protects DNA through cell cycle arrest (quiescence), senescence and apoptosis and shows what happens when the system breaks down... malignancy!

Links to cited references:
https://pubmed.ncbi.nlm.nih.gov/34083...
Yang C, Lou G, Jin WL. The arsenal of TP53 mutants therapies: neoantigens and bispecific antibodies. Signal Transduct Target Ther. 2021 Jun 3;6(1):219. doi: 10.1038/s41392-021-00635-y. PMID: 34083505; PMCID: PMC8175382.

Hsiue EH, et al. Targeting a neoantigen derived from a common TP53 mutation. Science. 2021 Mar 5;371(6533):eabc8697. doi: 10.1126/science.abc8697. Epub 2021 Mar 1. PMID: 33649166; PMCID: PMC8208645.
https://pubmed.ncbi.nlm.nih.gov/33649...