Which Antipsychotics Cause The Most Weight Gain?

Antipsychotic medications are powerful drugs that are used to treat more than psychotic conditions like schizophrenia. Many of them are FDA-approved to treat bipolar disorder and depression. Even though they work very well and fast, they have some big side effects like weight gain and insulin resistance, some more than others. A new research study has given us some insight on which ones are better and worse.

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References
Shymko G, Grace T, Jolly N, et al. Weight gain and metabolic screening in young people with early psychosis on long acting injectable antipsychotic medication (aripiprazole vs paliperidone). Early Interv Psychiatry. 2021;15(4):787–793

Højlund M, Lund LC, Andersen K, Correll CU, Hallas J. Association of Low-Dose Quetiapine and Diabetes. JAMA Netw Open. 2021;4(5):e213209. doi:10.1001/jamanetworkopen.2021.3209

Holt RIG. Association Between Antipsychotic Medication Use and Diabetes. Curr Diab Rep. 2019 Sep 2;19(10):96. doi: 10.1007/s11892-019-1220-8. PMID: 31478094; PMCID: PMC6718373.

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