Calculation of percent ionized of weak electrolytes

Percentage of ionized form of weak electrolyte at particular pH of the solution is important to assess its activity. For example, if a weakly acidic drug is significantly ionized at a particular physiological pH, the drug permeability is reduced across the membrane of the tissue. So for a significant absorption, the drug should be in unionized form but at the same time, for dissolution and solubility, it should be in ionized form. So it is a sensitive balance between ionized and unionized forms that determines bioavailability and distribution of the drugs into tissues.

0:00 Introduction
1:13 Percentage ionization
2:30 For a weak base
5:14 Solution to Working example 1
6:44 Solution to Working example 2
8:11 Solution to Working example 3

#weakelectrolytes
#ionization
#phofsolution