First Clinical Trial of Ketogenic Diet for Bipolar & Schizophrenia - Shebani Sethi, MD

Early data from the first clinical pilot trial of the ketogenic metabolic intervention for serious mental illness shows promising results that could transform how the field of psychiatry understands and treats serious mental illness.

“In this pilot study, we taught 22 patients with severe bipolar disorder or schizophrenia how to maintain a ketogenic diet. It was all real-world, meaning we didn’t control food intake in a temporary inpatient setting and we didn’t deliver meals, but instead taught patients how to buy and prepare their own food. Despite the severity of their mental illness, our patients were able to successfully adopt the ketogenic diet as a lifestyle change. However, there is a selection bias, as those who entered the study may have been a more motivated population.

After four months, our preliminary results were very encouraging: They included a 30% reduction in central abdominal fat, an 11% drop in BMI and a 17% drop in cardiac inflammation, as measured by a marker called high-sensitivity C-reactive protein. Perhaps most importantly, we saw a 30% improvement in our patients’ clinical global impression inventory, which is the gold-standard psychiatric assessment we use to evaluate symptoms of mental illness. Additionally, we saw improvements in sleep.”
Dr. Shebani Sethi - Stanford Metabolic Psychiatry Clinic

Dr. Shebani Sethi is a board-certified physician in psychiatry and obesity medicine, a clinical assistant professor of psychiatry at Stanford University, and the founding director of Stanford's metabolic psychiatry clinic. In this talk, she describes the preliminary findings from her pioneering study on ketogenic diets and mental illness.

Bio: https://profiles.stanford.edu/shebani...
Twitter: @ShebaniMD

This video was recorded at the first ever Metabolic Psychiatry roadmap retreat, hosted by Baszucki Group and the Milken Institute for Strategic Philanthropy in May, 2022 in Santa Barbara. The conference brought together physicians, neuroscientists, dieticians, entrepreneurs, venture capitalists and philanthropists to build community in the emerging field of Metabolic Psychiatry.

Learn more about metabolic psychiatry and meet the visionary Metabolic Mind Award Winners at https://tinyurl.com/Baszucki-Group

About us:
Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission over time will be to provide resources and build community in metabolic psychiatry.

JOIN OUR MAILING LIST AT https://metabolicmind.org/

Other resources for Metabolic Psychiatry, metabolic neuroscience and ketogenic metabolic therapy for mental disorders:

Diagnosis Diet - https://www.diagnosisdiet.com/

New Study: Serious Mental Illness Improves on Ketogenic Diet -
https://www.psychologytoday.com/us/bl...

The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review
https://www.ncbi.nlm.nih.gov/pmc/arti...
Chris Palmer MD - https://www.chrispalmermd.com/

Stanford Metabolic Psychiatry- https://metabolicpsychiatry.com/
What Is Metabolic Psychiatry? 5 Questions Answered by Dr. Shebani Sethi
https://med.stanford.edu/news/all-new...

Baszucki Group - https://baszuckigroup.com/our-work/me...

BipolarCast: Keto + Bipolar youtube channel, Hosted by Matt Baszucki and Iain Campbell, PhD
   / @bipolarcast1133  
  / iaincampbellphd  

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.


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