Plasma Protein Binding

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Plasma protein binding refers to the process by which drugs and other substances in the bloodstream attach to proteins within the plasma, primarily albumin, but also to globulins and other proteins. This binding affects the distribution, activity, and elimination of the drug within the body. When a drug is bound to plasma proteins, it is generally inactive and unable to exert its therapeutic effects or pass through cell membranes. Only the unbound or free portion of the drug is pharmacologically active and available to interact with target tissues. The extent of plasma protein binding influences the drug's half-life, bioavailability, and overall effectiveness, and it can also impact drug interactions, as different substances may compete for the same binding sites. Understanding plasma protein binding is crucial for determining appropriate dosing and maximizing the therapeutic efficacy of medications.

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