Скачать или смотреть Unraveling the Complexity of the Glucocorticoid Receptor: A Breakthrough in Drug Development

In this video, we delve into a groundbreaking study that has deciphered a crucial mechanism behind the glucocorticoid receptor (GR). Researchers have discovered that the GR forms oligomers, which opens up new possibilities for developing more selective drugs. These drugs could potentially modulate the association of GR subunits, minimizing adverse effects like immunosuppression and bone loss.
The study, led by Eva Estébanez-Perpiñá, reveals that the GR acts as a flexible protein with multiple conformations. It challenges the traditional model, showing that the receptor forms larger oligomers, primarily tetramers, within the cell nucleus. This discovery has significant implications for understanding the GR's role in regulating glycemia, metabolism, and the anti-inflammatory response.
Join us as we explore the team's findings, including the identification of 20 different association forms and the determination of the most relevant oligomeric forms for GR's physiological function. We'll also discuss the impact of mutations in the GR gene and how they can lead to aberrant forms and loss of protein functionality, as seen in Chrousos syndrome.
This research paves the way for precision drugs that can modulate GR function with unprecedented specificity, offering new hope for treating autoimmune, inflammatory, and other diseases associated with GR dysfunction.