Malignant Peripheral Nerve Sheath Tumor (MPNST) 101...Explained by a Sarcoma Pathologist

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

This video explores the clinical, histologic, and immunophenotypic features of MPNST. Malignant Triton tumor and epithelioid MPNST are also discussed. Over 15 different cases of MPNST are shown in the video. Cases/topics discussed (click time stamp to go to that part of the video):

Intro/clinical settings for MPNST: 0:00
MPNST histologic features: 7:00
Example of palisading in MPNST: 25:00 (see WSI digital slide for this case: )
IHC in MPNST: 36:50
Malignant Triton tumor (MPNST w rhabdomyoblastic differentiation): 42:48
Striated rhabdomyoblast in Triton tumor: 58:25
Epithelioid MPNST: 1:06:18

Additional relevant videos:
- Neurofibroma, NF-1, and low grade MPNST:    • Neurofibroma, Neurofibromatosis-1, an...  
- Schwannoma (neurilemmoma):    • Schwannoma (Neurilemmoma)...Explained...  
- Synovial sarcoma:    • Synovial Sarcoma 101…Explained by a S...  

Additional suggested reading:
- Atypical neurofibromatous neoplasms / "low grade MPNST" in setting of NF-1: https://www.ncbi.nlm.nih.gov/pubmed/2...
- Our case report of malignant Triton tumor MPNST arising in free flap: https://www.ncbi.nlm.nih.gov/pubmed/2....
Whole slide digital pathology images from the case:
- http://bit.ly/TritonFreeFlap1
- http://bit.ly/TritonFreeFlap2
- http://bit.ly/TritonFreeFlap3
- S100: http://bit.ly/TritonFreeFlapS100

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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