Скачать или смотреть CAR T-Cell Therapy City Boy

what's your favorite type of T cell? source footage: Peter MacCallum Cancer Centre CAR-T Cells: Engineered Cancer Killers, City of Hope CAR T Cell Therapy Explained (Animation) | City of Hope.

review by Sun, L., Su, Y., Jiao, A. et al. T cells in health and disease. Signal transduction and targeted therapy 8, 235 (2023).

"T lymphocytes (T cells) are the major cell components of the adaptive immune system, responsible for mediating cell-based immune responses to keep the host healthy and prevent various types of diseases. T cells are developed from bone marrow (BM)-derived thymocyte progenitors in the thymus, and broadly grouped into CD4+ and CD8+ αβ T cells in addition to rear populations of γδ T cells and NKT cells.

αβ T cells recognize antigens that are presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). Upon recognition of cognate antigens (signals 1) by T cell receptor (TCR) and costimulatory molecules (signals 2) on APCs, and cytokines (signals 3), naïve CD4+ and CD8+ T cells undergo activation, clonal expansion, and differentiation to execute their effector functions of destroying infected cells, producing cytokines and regulating immune responses. A small population of T cells develops into memory T cells which exhibit rapid effector functions upon reencountering the same antigens and provide the host with potent and long-term protection. In parallel, there exists a subpopulation of CD4+ T cells, named regulatory T (Treg) cells, that maintain peripheral immune tolerance."

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