Скачать или смотреть New labels from IOCB Prague allow scientists to see cellular processes more clearly

Thanks to a new study from IOCB Prague, it is now possible to monitor processes in living cells more effectively than ever before, including an organism’s response to drugs or changes in cellular structures.

The researchers have developed a new type of fluorescent labels that provide higher contrast and better visibility in images obtained by fluorescence microscopy. This discovery is important, for example, for medicine and the pharmaceutical industry.

The team led by Milan Vrábel and Tomáš Slanina from IOCB collaborated on the research with the chemical biology group of Péter Kele from Hungary.

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This work was supported by the Academy of Sciences of the
Czech Republic (RVO: 61388963), the Czech Science
Foundation (P207/24-10829S), by the National Institute for
Research of Metabolic and Cardiovascular Diseases (Programme
EXCELES, ID Project No. LX22NPO5104)
funded by the European Union Next Generation EU and
by the project New Technologies for Translational Research in
Pharmaceutical Sciences/NETPHARM, project ID
CZ.02.01.01/00/22_008/0004607, cofunded by the European
Union.

Original article:Šlachtová, V., Bím, D., Németh, K., Barańska, E., Bellová, S., Dračínský, M., Dzijak, R., Kele, P., Slanina, T., & Vrabel, M. (2025). Fluorescence quenching properties and bioimaging applications of readily accessible Blue to Far-Red fluorogenic triazinium salts. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5c17428