Скачать или смотреть Spatial immune dynamics in NSCLC after dual ICI or ICI-chemotherapy

Natalie Vokes, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, comments on findings from an imaging mass cytometry analysis of tumor samples from patients with non-small cell lung cancer (NSCLC) treated with dual immune checkpoint inhibition (ICI) or checkpoint inhibitors plus chemotherapy. Distinct immune and spatial patterns were observed across regimens, including higher regulatory T-cell infiltration and epithelial cell persistence after dual blockade, and broader immune cell infiltration with chemotherapy combinations. Differences in cell-cell interactions highlight how treatment-specific tumor microenvironment changes may shape therapeutic response and disease progression. This interview took place at 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain.

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