Integrating Type 2 symptoms into SLE management strategies

During the Lupus Hub Steering Committee Meeting, held on May 7, 2024, Murray Urowitz chaired a discussion on integrating Type 2 symptoms into management strategies for systemic lupus erythematosus (SLE), with contributions from Betty Diamond, and Laurent Arnaud.

Urowitz provided an overview of the key differences between the two types of lupus, highlighting the key symptoms of Type 2 lupus and their similarity to other conditions, such as COVID-19. He emphasized the importance of including these symptoms as outcome measures in clinical trials, and addressed patient–physician discordance and the need for a multidisciplinary approach involving social workers, nurses, psychologists, and psychiatrists. Although the pathogenesis of Type 2 lupus remains unclear, the steering committee members questioned the inflammatory contribution and the necessity of further investigation into its underlying mechanisms.