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The Overactive Bladder Biomechanical Spectrum: A Method for Pinpointing an Individual Based on Dynamic Elasticity and Spontaneous Rhythmic Contractions during Filling

Cullingsworth Z1, Li R1, Klausner A1, Speich J1

1. Virginia Commonwealth University

KEYWORDS: Overactive Bladder, Biomechanics, Detrusor Overactivity

Overactive bladder (OAB) is a multi-factorial progressive syndrome [1] in many individuals, and the severity is quantified using voiding diaries and validated, subjective questionnaires. However, there is no currently available objective method to identify the degree of OAB. Recent studies have used signal analysis techniques such as Fast Fourier Transform (FFT) analysis to objectively quantify the amplitude and frequency of spontaneously rhythmic contractions identified as Detrusor Overactivity (DO) [2]. Furthermore, comparative-fill urodynamics has been used to identify and quantify acute dynamic elasticity that is present in individuals without DO and diminished or absent in individuals with DO [3]. Dynamic elasticity is characterized by a reduction in vesical pressure (Pves) (loss of elasticity) during a bladder fill due to strain-induced stress softening (strain softening) caused by previous filling and passive emptying of the bladder, and a return of Pves (restoration of elasticity) during a fill caused by active voiding during the previous fill [3]. The purpose of the present study was to develop a method to pinpoint an individual on an OAB spectrum based on both their level of dynamic elasticity and the magnitude of any rhythmic contractile activity.

Read the full abstract text here: https://www.ics.org/2020/abstract/449